Rosie O’Donnell shared her experience taking the weight-loss drug Mounjaro, including the side effects. The former talk show host said she has “never felt better.” However, she revealed that she had lost 12 pounds without making any changes, leading her to worry that she might have cancer.
A rapid 12-pound weight drop in three weeks sent Rosie O’Donnell into health panic
O’Donnell spoke about the details on the August 11 episode of the Good Hang with Amy Poehler podcast. The 64-year-old said, as quoted by Us Weekly, “Three years ago, the doctor told me … they said, ‘You have diabetes, can you take a shot?’ I said, ‘I think so. I don’t know. I’ve never done a shot. Is it insulin?’ … They said, ‘No, it’s this new drug and it really helps with your blood sugar.'”
O’Donnell said she was never told that the medication could cause rapid weight loss. She said doctors were focused on getting her “numbers” down. After starting Mounjaro, O’Donnell went to Nobu but said she could not eat after her son Blake proposed to Teresa Garofalow Westervelt. The couple got married in 2024. O’Donnell is also the mother of Parker, 31, Chelsea, 28, Vivienne, 23, and Clay, 13.
The comedian said she was overwhelmed with emotion after missing her mother, Roseann, and wishing she could have witnessed Blake’s engagement and new chapter in life. She initially believed that emotional experience explained her weight loss. However, two weeks later, “I get on the scale. I call my doctor crying. I must have cancer. I’ve lost 12 pounds and I haven’t done anything. It’s been three weeks since I started that medicine.”
O’Donnell, who first opened up about taking Mounjaro in January 2023, explained that losing weight had always been difficult for her, even when she actively tried. She said the drug could help many people with obesity but criticized the high cost of the treatment.
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